What Is the Added Benefit of Oropharyngeal Swabs Compared to Nasal Swabs Alone for Respiratory Virus Detection in Hospitalized Children Aged <10 Years?

What Is the Added Benefit of Oropharyngeal Swabs Compared to Nasal Swabs Alone for Respiratory Virus Detection in Hospitalized Children Aged <10 Years?

J Infect Dis. 2015 Nov 15;212(10):1600-3. doi: 10.1093/infdis/jiv265. Epub 2015 May 5.

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Description

Author information:
1. Influenza Division.
2. Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City.
3. Hospital Del Niño.
4. Hospital De Especialidades Pediátricas Omar Torrijos.
5. Hospital Materno Infantil José Domingo De Obaldía, David, Panama.
6. Hospital San Juan De Dios, Santa Ana.
7. Hospital San Juan De Dios, San Miguel, El Salvador.
8. Gorgas Memorial Institute for Health Studies, Panama City.
9. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Abstract
We evaluated the added value of collecting both nasal and oropharyngeal swabs, compared with collection of nasal swabs alone, for detection of common respiratory viruses by reverse transcription-polymerase chain reaction in hospitalized children aged <10 years. Nasal swabs had equal or greater sensitivity than oropharyngeal swabs for detection of respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus, and influenza virus but not parainfluenza virus. The addition of an oropharyngeal swab, compared with use of a nasal swab alone, increased the frequency of detection of each respiratory virus by no more than 10% in children aged <10 years.

PMID: 25943205 [Indexed for MEDLINE]

Publication types
• Comparative Study
• Randomized Controlled Trial
• Research Support, U.S. Gov’t, P.H.S.
MeSH terms
• Child
• Child, Hospitalized
• Child, Preschool
• Humans
• Infant
• Infant, Newborn
• Molecular Diagnostic Techniques
• Mouth/virology*
• Nasal Cavity/virology*
• Prospective Studies
• Respiratory Tract Infections/diagnosis*
• Respiratory Tract Infections/virology
• Reverse Transcriptase Polymerase Chain Reaction
• Sensitivity and Specificity
• Specimen Handling/methods*
• Virus Diseases/diagnosis*
• Virus Diseases/virology*
• Viruses/isolation & purification*

 

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